Lyophilized Microspheres and Bulk Freeze Drying: Breakthrough Technology. Breakthrough Advantages!
MERIDION Technologies offer you new opportunities:
- Product Innovation
- Manufacturing Flexibility
- Process Robustness
- Total Containment
- Significant Cost Reductions
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Manufacturing flexibility and cost savings
Filling of lyophilized product on demand
- Filling quantities as required
- Contained product handling by gravity: no need for loading and unloading systems in sterile area
- Vial/final recipient flexibility: no specific freeze drying requirements for primary packaging
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Innovation & formulation flexibility
- Multicomponent formulations achieved by combining different lyophilized products in the final recipient (vial), e.g. to overcome incompatibilities
- Further modifications of product properties esp. in the area of Solid Dosage Forms like ODTs, Fast Dispersible Formulations, by applying known technologies so far not applicable to lyophilized compounds
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MERIDION SprayCon: Spray Freezing of Microspheres
Frozen microspheres are generated by dispersing the substrate liquid using high precision nozzles into monosized single droplets, which by gravity pass through a cooling zone, congealing to frozen spheres.
- Narrow particle size distribution
- Size selectable from 250 µm – 800 µm
- After freeze drying, the product
- is homogeneous,
- has excellent flow properties
- is dust free
Product innovation
- Further processing of the lyophilized spheres, e.g. by coating or by combination of products is possible
- Highly cost effective utilization of cooling energy – no direct contact with primary cooling agent
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MERIDION LyoMotion: Dynamic Bulk Freeze Drying
In the dynamic freeze drying process, flowable bulkware is lyophilized in a rotational freeze dryer under constant gentle mixing. Sublimation energy is transferred by radiation and temperature controlled surfaces.
MERIDION LyoMotion: Advantages and characteristic features
MERIDION LyoMotion: Advantages and characteristic features
Product quality
- Homogeneous, dust free product due to constant and gentle mixing – no caking, no variations in product density
- Direct monitoring of product temperature
Up to 50% reduced drying times by
- maximized heat and mass transfer (entire particle surface available)
- heat transfer directly to the product
- maximized flow of vapor – no limitation by stoppers or diffusion barriers of larger product layers
Process robustness
- Direct monitoring of product relevant parameters
- OOS results reduced
- PAT tools directly accessible
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